Integrated 3D-printed reactionware for chemical synthesis and analysis. / Symes, Mark D.; Kitson, Philip J.; Yan, Jun; Richmond, Craig J.; Cooper, Geoffrey J. T.;. ARTICLES PUBLISHED ONLINE: 15 APRIL | DOI: /NCHEM Integrated 3D-printed reactionware for chemical synthesis and analysis Mark D. Integrated 3D-printed reactionware for chemical synthesis and analysis. Mark D. Symes, Philip J. Kitson, Jun Yan, Craig J. Richmond, Geoffrey J. T. Cooper.

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In fact they are not generally recommended for exposure to alcohol, glycols, alkalis, brake fluids, or to chlorinated or aromatic hydrocarbons [20]. Saeed Bastani 7 Estimated H-index: Erkal Michigan State University.

Schematic representation of the 3D-printed reactionware devices employed in this work showing the internal channels. Further, the versatility of the 3D-printed reactionware has been demonstrated by studying and optimizing the residence time to synthesize a range of imines and secondary amines and to monitor the reactions in real time using integraetd IR spectroscopy. CoO6 units, and the terminal water ligand on one Co centre is sub- Information for experimental details and full characterization stituted by a chloride.

3D-printed devices for continuous-flow organic chemistry

The license is subject to the Beilstein Journal of Organic Chemistry terms and conditions: Reprints and permission information is available online at http: Schematic representation of the 3D-printed reactionware devices employed in this work showing the i Kitson and Leroy Cronin.


His synthssis interests are in the development of emerging technologies such as 3D printing for use in chemical synthesis. The use of this design and fabrication process gives chemists control over their chemistry by manipulating the geometry, topology and composition of their reaction vessel for specific applications.

To this end, we thinned acetoxysilicone bathroom sealant Supplementary Information and Supplementary Fig.


Pd—C induced catalytic transfer of hydrogen with triethylsilane. All other parameters were 3D-printed reactors. Moreover, on termination of the potential cycling at The subsequent crystallization events were bathroom sealant, LOCTITE as the primary material and monitored through the transparent viewing window incorporated inserting the non-printable components glass frit and microscope into the device see Supplementary Video S1.

Showing of 65 extracted citations. Although the chemistry chosen to exemplify this tech- — Table of the compounds used to study the imine reduction. The two electrodes of the cell were then connected to a three-elec- trode potentiostat, as shown in Fig.

Kitson University of GlasgowMark D.

Nature— We have demonstrated that it is possible to integrate 3D-printed reactionware devices into a flow system, which highlights the great versatility and modularity of 3D-printed reaction devices. In conclusion, we have demonstrated the production and utility of Go to reference Architecture as Topic Search for additional papers on this topic. The structure thus obtained is shown in after a week if amines are che,ical.

Therefore it represents a very attractive way to design and build new continuous-flow rigs for organic synthesis. KitsonStefan Glatzel and Leroy Cronin. This 3D printer heats a thermopolymer through the extruder, depositing the material in a layer-by-layer fashion, converting the design into the desired 3D reactionware.


We monitored the reaction progress with the help of an in-line ATR-IR flow cell, which is a very useful technique for the monitoring of organic reactions under flow conditions [10,]. WeaverYuqi LiRussell A. From multiuse electrochemical cells to sensors.

Predictive modeling in homogeneous thermogravimetric analyses, crystallographic data and notes on and diagrams of the catalysis: Imine formation Device 2: The syringe pumps were filled with the starting materials with a carbonyl compound synthfsis — c being placed in syringe pump no. Organometallics22, — In both graphs the imine spectrum in red is compared with the spectrum of the starting materials dash line: The choice of a short residence time is to allow for a more reliable comparison of the imines synthesized and also to avoid the formation of the Michael addition adduct [28] the thermodynamic compound in the reaction between compounds 1b and 2a.

One chamber at a controlled rate. Jump to Figure 7. Digital technology was used to design and